Genome Structure Defines Breast Cancers
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Breast cancersScienceDaily
•Health
Health
Breast cancers broadly defined by their genome architecture
80% Informative
Study hints at tumor origin, vulnerabilities.
Targeting these processes early is likely to offer unexpected therapeutic avenues.
Researchers at Stanford Medicine have shown that these subgroups can be bundled into three main groups based on structural variations in their DNA.
These variations are established early during cancer development and maintained as the disease advances.
Study: Triple-negative tumors had genomes that were globally unstable, accumulating alterations across the genome.
Each had complex but localized amplifications of cancer-associated genes as well as small DNA circles called extrachromosomal DNA, or ecDNA.
The structural variations that define each group were present in the earliest stages of the disease and were maintained as the tumors grew.
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