PIN1 inhibits bladder cancer growth
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PIN1 inhibitor sulfopinScienceDaily
•Putting a lid on excess cholesterol to halt bladder cancer cell growth
78% Informative
Bladder cancer is one of the most diagnosed cancers worldwide and the fourth most common cancer among men.
Researchers at the Salk Institute have discovered that PIN1 is a significant driver of bladder cancer.
A combination of existing drugs, including statins, blocks tumor growth in mice.
Removing PIN1 effectively put a lid on the cancer's fuel supply.
Simvastatin , a widely prescribed statin , to block HMGCR, and sulfopin to disable PIN1.
The two worked better in tandem than as individual treatments.
"This is likely just one of many roles that PIN1 plays in cancers," says Hunter .
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