DNA, Magnesium Balance Discovery
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polyphosphateScienceDaily
•Scientists discover a 'Goldilocks' zone for DNA organization, opening new doors for drug development
79% Informative
Scripps Research Institute's new study uncovers how DNA, magnesium and polyphosphate form a balance that's just right -- which could lead to innovations in medicine and biotechnology.
Study reveals a delicate "Goldilocks" zone -- a specific magnesium concentration range -- where DNA wraps around polyP-magnesium ion condensates.
DNA wraps itself around a condensate, creating a thin eggshell-like barrier.
Researchers suspect DNA interactions with polyP condensates in cells might propagate local changes in DNA supercoiling over long distances.
Investigating this effect is one of the team's next goals.
"We're excited by the prospects of leveraging these discoveries to develop new tools for cellular control," says Deniz .
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