IL-38 Disrupts Skin Renewal Mechanisms
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keratinocytesScienceDaily
•A new model to explore the epidermal renewal
77% Informative
Interleukin-38 (IL-38), a protein involved in regulating inflammatory responses, could be a game changer.
A team from the University of Geneva ( UNIGE ) has observed it for the first time in the form of condensates in keratinocytes, the cells of the epidermis .
Presence of IL-38 in these aggregates is enhanced close to the skin's surface exposed to atmospheric oxygen.
This process could be linked to the initiation of programmed keratinocyte death, a natural process.
Cell Reports, 2024 ; 43 ( 11): 114940 .
Oxidation-sensitive cysteines drive IL-38 amyloid formation.
System will provide an alternative to animal models often used for the study of skin biology and disease.
New system will provide a more precise analysis of human cells.
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