Computational Approach to Immune Interactions

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immune system perturbations

Phys Org

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New modeling of complex biological systems could offer insights into genomic data and other huge datasets

Summary

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MIT engineers have developed a new computational method for extracting useful information from complex biological systems.

Using their new technique, they showed that they could unravel a series of interactions that determine how the immune system responds to TB vaccination and subsequent infection.

This strategy could be useful to vaccine developers and to researchers who study any kind of complex biological system.

Researchers used a model to make predictions for how a specific disruption would affect the immune system.

The model predicted that if B cells were nearly eliminated, there would be little impact on the vaccine response.

Lauffenburger 's lab is now using the model to study the mechanism of a malaria vaccine given to children in Kenya , Ghana and Malawi .

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English

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