New Method Relocates Missing Proteins

This is a news story, published by ScienceDaily, that relates primarily to FUS news.

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protein relocalization

ScienceDaily

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Bringing lost proteins back home

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A new method for relocating proteins that have been misplaced in cells could mean new treatments for cancers and neurodegeneration.

The method involves rewiring the activity of naturally occurring shuttles to help move proteins to different parts of the cell.

The team developed a new class of molecules called "targeted relocalization activating molecules" or TRAMs.

Stanford researchers created a TRAM that would relocalize FUS , the protein that gets shipped out of the nucleus and forms dangerous granules in ALS patients.

After treating cells with their TRAM , the team saw that FUS was transported back into its natural home in the nucleus.

They then turned their attention to a well-known mutation in mice that makes them more resistant to neurodegeneration.

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