Epigenetic reprograms astrocytes into brain stem cells

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Epigenetic changes reprogram astrocytes

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Epigenetic changes reprogram astrocytes into brain stem cells

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Epigenetic changes reprogram astrocytes into brain stem cells.

Scientists from the German Cancer Research Center ( DKFZ ) and Heidelberg University have published their findings in the journal Nature .

In mice, a lack of blood supply in the brain epigenetically reprograms astrocetes into stem cells, which in turn can give rise to nerve progenitor cells.

Discovery shows that astrocycles could potentially be used in regenerative medicine to replace damaged nerve cells.

The lack of blood supply apparently causes astrocytes in certain areas of the brain to redistribute the methyl marks on their DNA in such a way that their stem cell program becomes accessible.

Epigenetic reprogramming cannot be observed in living animals using imaging techniques, but requires studies at the level of individual cells.

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