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Home | Molecular Pharmacology

Home | Molecular Pharmacology

Ketamine and major ketamine metabolites function as allosteric modulators of opioid receptors

Home | Molecular Pharmacology
Summary
Nutrition label

81% Informative

Ketamine is a glutamate receptor antagonist that was developed over 50 years ago as an anesthetic agent.

At subanesthetic doses, ketamine and some metabolites are analgesics and fast-acting antidepressants, presumably through targets other than glutamate receptors.

All three opioid receptors (mu, delta, and kappa) showed synergism with submicromolar concentrations of ketamine .

This allosteric activity may contribute to ketamine’s therapeutic effectiveness for treating acute and chronic pain.

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89

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formal

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English

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100

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long-living

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