DNA Methylation Predicts Epilepsies

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specific gene methylation

ScienceDaily

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Genetic 'episignatures' guide researchers in identifying causes of unsolved epileptic neurological disorders

Summary

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Scientists at St. Jude Children's Research Hospital demonstrate value of DNA methylation patterns for identifying the root cause of DEEs.

The findings were published today in Nature Communications .

DEEs affect 1 in 590 children and involve more than 825 genes.

80% of identifiable DEEs can be explained by 27 genes.

Christy W. LaFlamme , Cassandra Rastin , Soham Sengupta , Helen E. Pennington , Sophie J. Russ-Hall , Amy L. Schneider , Emily S. Bonkowski , Edith P. Almanza Fuerte , Talia J. Allan , Miranda Perez-Galey Zalusky , Joy Goffena , Sophia B. Gibson , Denis M. Nyaga , Nico Lieffering, Malavika Hebbar , Emily V. Walker , Scott R. Olsen , Pandurang Kolekar , Mohamed Nadhir Djekidel , Wojciech Rosikiewicz .